构建处置模型（Disposition）
1) 通过静注后人的PK数据拟合
2) 或通过体外及动物资料预测
用GastroPlus搭建模型
1) 用GastroPlus的吸收模型（ACAT），连接处置模型
2) 用该药其它制剂的 PK 资料优化不确定的参数
验证后的模型可用于
– 鉴定限制生物利用度的关键性因素，指导后续制剂研发；
– 模拟不同给药方案下 PK 的变化；
– 建立体内外相关性 IVIVC，确定最反映体内溶出的体外溶出条件
– 指导体外溶出标准的制定；
– 模拟虚拟生物等效性试验；
– 建立 PK-PD 模型，评估不同剂型、剂量、给药方案下，药效的变化；
– 药物药物相互作用 DDI;
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Can you be more specific about the content of your article? After reading it, I still have some doubts. Hope you can help me.
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I don’t think the title of your article matches the content lol. Just kidding, mainly because I had some doubts after reading the article.
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Your point of view caught my eye and was very interesting. Thanks. I have a question for you.
Thank you for your sharing. I am worried that I lack creative ideas. It is your article that makes me full of hope. Thank you. But, I have a question, can you help me?
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