NONMEN输出结果
最重要的输出文件lst文件
iv infusion 3cp\infusion_3cp.nm7\infusion_3cp.lst
简洁输出文件
iv infusion 3cp\infusion_3cp.nm7\infusion_3cp.smr
控制文件和软件授权信息
lst文件内
1. 完整运行的控制文件
2. 授权信息
License Registered to: XXXX ;购买软件许可的机构
Expiration Date: XXXX ;到期时间
Current Date: XXXX ;当前日期
Days until program expires : XXX ;软件授权剩余天数
NM-TRAN
NO. OF DATA RECS IN DATA SET: 475 数据行数
NO. OF DATA ITEMS IN DATA SET: 17 数据变量数
ID DATA ITEM IS DATA ITEM NO.: 2 ID所在列
DEP VARIABLE IS DATA ITEM NO.: 6 观测值所在列
MDV DATA ITEM IS DATA ITEM NO.: 9 MDV所在列
PREDPP
房室相关信息
COMPT. NO. FUNCTION INITIAL ON/OFF DOSE DEFAULT DEFAULT
STATUS ALLOWED ALLOWED FOR DOSE FOR OBS.
1 CENTRAL ON NO YES YES YES
2 PERIPH1 ON NO YES NO NO
3 PERIPH2 ON NO YES NO NO
4 OUTPUT OFF YES NO NO NO
给药信息
EVENT ID DATA ITEM IS DATA ITEM NO.: 17
TIME DATA ITEM IS DATA ITEM NO.: 3
DOSE AMOUNT DATA ITEM IS DATA ITEM NO.: 7
DOSE RATE DATA ITEM IS DATA ITEM NO.: 8
估算方法
估算方法
ANALYSIS TYPE: POPULATION
NUMBER OF SADDLE POINT RESET ITERATIONS: 0
GRADIENT METHOD USED: NOSLOW
CONDITIONAL ESTIMATES USED: YES
CENTERED ETA: NO
EPS-ETA INTERACTION: YES
LAPLACIAN OBJ. FUNC.: NO
NO. OF FUNCT. EVALS. ALLOWED: 9999
NO. OF SIG. FIGURES REQUIRED: 3
中间运算结果
**ITERATION NO.: 0 (迭代次数 )**
**OBJECTIVE VALUE: 2303.85369963211 （目标函数值）**
**NO. OF FUNC. EVALS.: 10 （函数估算次数）**
**CUMULATIVE NO. OF FUNC. EVALS.: 10（累计估算次数）**
参数估算值
NPARAMETR: 5.0558E+01 1.0513E+01 1.5310E+01 4.1132E+01 1.9719E+01 2.0763E+01 1.9992E-02 1.9970E-02 2.0115E-02 2.0149E-02
2.0703E-02 9.5814E-02
PARAMETER: 5.8496E-02 1.4998E-01 1.2045E-01 1.2790E-01 8.5875E-02 1.3745E-01 9.9789E-02 9.9257E-02 1.0287E-01 1.0371E-01
1.1728E-01 7.8620E-02
梯度
GRADIENT: 1.0307E+02 -1.2413E+02 -5.0791E+01 -6.9290E+01 3.5080E+01 -9.3004E+01 5.2462E-01 1.8444E+00 -7.1247E+00 -9.2107E+00
-4.2924E+01 5.3097E+01
结果示例：
0ITERATION NO.: 0 (迭代次数 ) OBJECTIVE VALUE: 2303.85369963211 NO. OF FUNC. EVALS.: 10
CUMULATIVE NO. OF FUNC. EVALS.: 10
NPARAMETR: 5.2700E+01 1.0000E+01 1.5000E+01 4.0000E+01 2.0000E+01 2.0000E+01 2.0000E-02 2.0000E-02 2.0000E-02 2.0000E-02
2.0000E-02 1.0000E-01
PARAMETER: 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01
1.0000E-01 1.0000E-01
GRADIENT: 1.0307E+02 -1.2413E+02 -5.0791E+01 -6.9290E+01 3.5080E+01 -9.3004E+01 5.2462E-01 1.8444E+00 -7.1247E+00 -9.2107E+00
-4.2924E+01 5.3097E+01
0ITERATION NO.: 1 OBJECTIVE VALUE: 2294.06567680895 NO. OF FUNC. EVALS.: 12
CUMULATIVE NO. OF FUNC. EVALS.: 22
NPARAMETR: 5.0558E+01 1.0513E+01 1.5310E+01 4.1132E+01 1.9719E+01 2.0763E+01 1.9992E-02 1.9970E-02 2.0115E-02 2.0149E-02
2.0703E-02 9.5814E-02
PARAMETER: 5.8496E-02 1.4998E-01 1.2045E-01 1.2790E-01 8.5875E-02 1.3745E-01 9.9789E-02 9.9257E-02 1.0287E-01 1.0371E-01
1.1728E-01 7.8620E-02
GRADIENT: -4.3681E+01 -2.1561E+00 -2.0097E+01 -1.3147E+01 -1.5383E+01 -6.9617E+00 2.9926E+00 6.2304E+00 -5.3722E+00 -9.2730E+00
-2.0838E+01 5.0299E+01
0ITERATION NO.: 2 OBJECTIVE VALUE: 2290.80399734753 NO. OF FUNC. EVALS.: 12
CUMULATIVE NO. OF FUNC. EVALS.: 34
NPARAMETR: 5.2420E+01 1.0669E+01 1.5721E+01 4.2003E+01 1.9975E+01 2.1114E+01 1.9862E-02 1.9700E-02 2.0376E-02 2.0589E-02
2.1831E-02 8.5164E-02
PARAMETER: 9.4666E-02 1.6475E-01 1.4696E-01 1.4887E-01 9.8735E-02 1.5421E-01 9.6548E-02 9.2436E-02 1.0931E-01 1.1451E-01
1.4379E-01 1.9707E-02
GRADIENT: 5.9994E+01 3.8143E+01 -3.2317E-01 4.7986E+00 -8.0643E+00 1.3449E+01 2.6998E+00 5.7923E+00 -4.8725E+00 -9.2573E+00
-3.1531E+00 4.2503E+01
0ITERATION NO.: 3 OBJECTIVE VALUE: 2286.96069628843 NO. OF FUNC. EVALS.: 11
CUMULATIVE NO. OF FUNC. EVALS.: 45
NPARAMETR: 5.1687E+01 1.0348E+01 1.6216E+01 4.2732E+01 2.0526E+01 2.1135E+01 1.9585E-02 1.9121E-02 2.0916E-02 2.1572E-02
2.3392E-02 6.7229E-02
PARAMETER: 8.0596E-02 1.3423E-01 1.7792E-01 1.6608E-01 1.2596E-01 1.5519E-01 8.9506E-02 7.7534E-02 1.2240E-01 1.3783E-01
1.7832E-01 -9.8533E-02
GRADIENT: -2.4643E+00 -3.0654E+00 3.5601E+01 -1.4332E+01 5.5020E+01 -7.8835E+00 3.6861E+00 6.3920E+00 -4.3786E+00 -9.5467E+00
2.6582E+01 2.6217E+01
最终模型的参数估算值
MINIMIZATION SUCCESSFUL 最小化成功
NO. OF FUNCTION EVALUATIONS USED: 317 函数估算次数
NO. OF SIG. DIGITS IN FINAL EST.: 3.4 函数估算有效位数
ETA统计：算术平均值，方差，统计个数，se的p值（与0比较）
ETABAR: -5.4972E-04 1.6467E-04 -5.9433E-03 0.0000E+00 5.9833E-03 0.0000E+00
SE: 2.1583E-02 1.0976E-02 1.7510E-02 0.0000E+00 2.6573E-02 0.0000E+00
N: 36 36 36 36 36 36
P VAL.: 9.7968E-01 9.8803E-01 7.3430E-01 1.0000E+00 8.2185E-01 1.0000E+00
ETA与EPS的收缩
ETASHRINKSD(
ETASHRINKVR(
EBVSHRINKSD(
EBVSHRINKVR(
EPSSHRINKSD(
EPSSHRINKVR(
TOTAL DATA POINTS NORMALLY DISTRIBUTED (N): 439 总体观测事件个数
TOTAL DATA POINTS NORMALLY DISTRIBUTED (N): 439 个体间变异ETA值的个数
剩余时间
Elapsed estimation time in seconds: 6.27
Elapsed covariance time in seconds: 9.47
Elapsed postprocess time in seconds: 0.07
终模型的参数估算值
最小目标函数值（ #OBJV:）
************************************************************************************************************************
******************** ********************
******************** FIRST ORDER CONDITIONAL ESTIMATION WITH INTERACTION ********************
#OBJT:************** MINIMUM VALUE OF OBJECTIVE FUNCTION ********************
******************** ********************
************************************************************************************************************************
#OBJV:******************************************** 2279.447 **************************************************
典型值 THETA - VECTOR OF FIXED EFFECTS PARAMETERS
************************************************************************************************************************
******************** ********************
******************** FIRST ORDER CONDITIONAL ESTIMATION WITH INTERACTION ********************
******************** FINAL PARAMETER ESTIMATE ********************
******************** ********************
************************************************************************************************************************
THETA - VECTOR OF FIXED EFFECTS PARAMETERS *********
TH 1 TH 2 TH 3 TH 4 TH 5 TH 6
5.15E+01 1.05E+01 2.12E+01 4.85E+01 1.45E+01 1.34E+01
个体间变异方差矩阵OMEGA - COV MATRIX FOR RANDOM EFFECTS - ETAS
OMEGA - COV MATRIX FOR RANDOM EFFECTS - ETAS ********
ETA1 ETA2 ETA3 ETA4 ETA5 ETA6
ETA1
+ 1.88E-02
ETA2
+ 0.00E+00 1.18E-02
ETA3
+ 0.00E+00 0.00E+00 2.66E-02
ETA4
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00
ETA5
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 4.19E-02
ETA6
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
```
**残差变异的方差**（加和型和比例型）
```
SIGMA - COV MATRIX FOR RANDOM EFFECTS - EPSILONS ****
EPS1 EPS2
EPS1
+ 2.21E-02
EPS2
+ 0.00E+00 4.71E-02
1
```
**个体内变异系数**（100
```
OMEGA - CORR MATRIX FOR RANDOM EFFECTS - ETAS *******
ETA1 ETA2 ETA3 ETA4 ETA5 ETA6
ETA1
+ 1.37E-01
ETA2
+ 0.00E+00 1.09E-01
ETA3
+ 0.00E+00 0.00E+00 1.63E-01
ETA4
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00
ETA5
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 2.05E-01
ETA6
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
加和型和比例型残差变异系数百分比的变异系数
SIGMA - CORR MATRIX FOR RANDOM EFFECTS - EPSILONS ***
EPS1 EPS2
EPS1
+ 1.49E-01
EPS2
+ 0.00E+00 2.17E-01
1
各个参数的标准误
************************************************************************************************************************
******************** ********************
******************** FIRST ORDER CONDITIONAL ESTIMATION WITH INTERACTION ********************
******************** STANDARD ERROR OF ESTIMATE ********************
******************** ********************
************************************************************************************************************************
THETA - VECTOR OF FIXED EFFECTS PARAMETERS *********
TH 1 TH 2 TH 3 TH 4 TH 5 TH 6
1.32E+00 4.34E-01 4.05E+00 4.20E+00 3.83E+00 4.70E+00
OMEGA - COV MATRIX FOR RANDOM EFFECTS - ETAS ********
ETA1 ETA2 ETA3 ETA4 ETA5 ETA6
ETA1
+ 6.01E-03
ETA2
+ ......... 7.52E-03
ETA3
+ ......... ......... 1.83E-02
ETA4
+ ......... ......... ......... .........
ETA5
+ ......... ......... ......... ......... 2.02E-02
ETA6
+ ......... ......... ......... ......... ......... .........
SIGMA - COV MATRIX FOR RANDOM EFFECTS - EPSILONS ****
EPS1 EPS2
EPS1
+ 1.64E-03
EPS2
+ ......... 1.04E-02
1
OMEGA - CORR MATRIX FOR RANDOM EFFECTS - ETAS *******
ETA1 ETA2 ETA3 ETA4 ETA5 ETA6
ETA1
+ 2.20E-02
ETA2
+ ......... 3.46E-02
ETA3
+ ......... ......... 5.61E-02
ETA4
+ ......... ......... ......... .........
ETA5
+ ......... ......... ......... ......... 4.93E-02
ETA6
+ ......... ......... ......... ......... ......... .........
SIGMA - CORR MATRIX FOR RANDOM EFFECTS - EPSILONS ***
EPS1 EPS2
EPS1
+ 5.52E-03
EPS2
+ ......... 2.39E-02
方差协方差矩阵
************************************************************************************************************************
******************** ********************
******************** FIRST ORDER CONDITIONAL ESTIMATION WITH INTERACTION ********************
******************** COVARIANCE MATRIX OF ESTIMATE ********************
******************** ********************
************************************************************************************************************************
相关系数矩阵
************************************************************************************************************************
******************** ********************
******************** FIRST ORDER CONDITIONAL ESTIMATION WITH INTERACTION ********************
******************** CORRELATION MATRIX OF ESTIMATE ********************
******************** ********************
************************************************************************************************************************
协方差逆矩阵
************************************************************************************************************************
******************** ********************
******************** FIRST ORDER CONDITIONAL ESTIMATION WITH INTERACTION ********************
******************** INVERSE COVARIANCE MATRIX OF ESTIMATE ********************
******************** ********************
************************************************************************************************************************
特征值结果
************************************************************************************************************************
******************** ********************
******************** FIRST ORDER CONDITIONAL ESTIMATION WITH INTERACTION ********************
******************** EIGENVALUES OF COR MATRIX OF ESTIMATE ********************
******************** ********************
************************************************************************************************************************
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